PREFACE.

It is not necessary to inform the reader that this BULLETIN comprises but a fragment of what needs be recorded, were it our object to present a complete history of the Concentration feature of the American materia medica and its journey within the dates embraced herein. Every page carries its own suggestion of complications in connected or outside lines that must necessarily be wholly neglected, or touched but briefly. Every personage mentioned and every incident depicted leads to some feature of importance that merits more than a passing notice; so much so, that it appears to the author as though the most vital parts of the BULLETIN are too much abridged. To attempt to explain intelligently the many features closely connected with the contents of this BULLETIN would necessitate detailed descriptions and histories of adjacent lines of compounds, as well as of connected classes of pharmaceutical preparations, that in
themselves merit as comprehensive a study as the author has herein given the “American Concentrations.” Indeed, the necessity of doing justice, even though but scant, to our subject, and yet of neglecting exceptionally interesting subjects, or evading many interlocked complications that uprise in this or that direction, has been one of the most perplexing features of this attempt to make a comprehensive but brief record of the American concentrations, alkaloids, and resinoids. In every direction it seemed as though the efforts of the persons concerned in the products under consideration were irrevocably interlaced with other features of this American problem.
For example, the pharmacy of the crude mixtures, decoctions, infusions, and acetates of the early days, the fluid and solid extracts, the essential tinctures, concentrated tinctures, Specific Medicines, and such, of more recent days, as well as the alkaloids, glucosids, and essential oils are not directly embraced in the scope of this publication, but are nevertheless intricately involved therein.

It will be perceived that the so-called Eclectic resinoids, alkaloids, and resins were intruded into the passing along of the science of pharmacy, materia medica, and medicine of the nineteenth century, much as a foreign body, for a temporary purpose, becomes a part of a structure from which it is afterwards excised, leaving in the end a few
remnants only to tell the story of its former usefulness. It is as the superstructure to a bridge that, supporting the incomplete edifice, is vital to its very construction, but yet, is finally torn away by its own Eclectic Alkaloids - J.U.Lloyd

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builders. All of this, however, and much that needs not be referred to in detail, will unquestionably appeal to the intelligent reader, as it does to the author, who fully, but yet regretfully, comprehends that which lies in the outreaches beyond the subject under discussion.

As concerns the American materia medica, its pharmacy and record, the author therefore considers this BULLETIN as merely an introductory chapter, which, with others yet unwritten, antedating as well as following this, would make the story complete. Nor does he hesitate to confess that he hopes some day to supply the missing chapters, as he has learned them. But should want of time necessitate, he must leave this most fascinating subject to the enjoyable opportunity of others.

It has been deemed advisable to introduce portraits of the principal persons involved in this record of the past. Most of those presented were in former times personal friends or acquaintances of the author, but all have passed away. The biographical sketches accompanying the portraits seem naturally, to the author, very brief, but he hopes that enough useful information is presented to introduce each fairly to the reader. Detailed descriptions of the lives of some of these men would necessitate a volume.

It may seem to our readers that many to whom reference is made in this work, but who yet are not portrayed, are even more important than some here presented. This the author appreciates, but will add that in many instances, as with Beach and Scudder, their most conspicuous work was in other sections of the American materia medica and pharmacy, and when such portions of the work are taken up in detail, whoever has that responsibility will surely find it necessary to portray and give biographical references to these men.
Should the author be permitted to complete this study, as he has intimated he hopes may be the case, such men as Greve, Proctor,
Parrish, Squibb, Zollickoffer, Waterhouse, Thacher, Dunglison, Cullom, and others who could well have a place here, but whose work was more conspicuous elsewhere, will surely be presented. Some there were, like Mr. B. Keith, of New York, who should here be presented on account of their prominence in the evolution of the “American Concentrations,” but although no effort was spared to obtain biographical data or a portrait, this was found impossible at this late period, much to the author's regret. For a different reason, no special place is given to either Samuel Thomson or B. S. Barton, M. Eclectic Alkaloids -

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D., the former of whom is the subject of Lloyd Library Bulletin Number II, while Lloyd Library Bulletin Number I reproduces the “Collections” of Barton, both of these Bulletins carrying frontispiece portraits, as well as biographies of the authors named. In consequence of the fact that the portraits would have been too closely crowded together, had they been placed in connection with the pages referring to each, they are distributed promiscuously throughout the work . (They are at the end—MM)

The author desires to extend his special thanks to Professor Harvey Wickes Felter, M. D., to whom he is indebted for the photograph of Dr. John King, as well as to his biographies of the two Newtons and Dr. Wilder, in the Eclectic Medical Gleaner, published under the auspices of the Lloyd Library. Thanks are due also to the Librarian of the Lloyd Library, William Holden, M. D., and his Assistant, Miss Edith Wycoff, as well as to the Secretary of the author, Miss Margaret Stewart. To all of these the author is deeply grateful, and to their watchful care this BULLETIN owes much.

For the biographies, the footnotes, and all uncredited material of this BULLETIN the author is responsible.

JOHN URI LLOYD.

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The Eclectic Alkaloids, Resins, Resinoids, Oleo-

Resins and Concentrated Principles.

HISTORY (1839-1910.)

Condition in Therapy Preceding the Concentrations—

The story of the “Eclectic Concentrations” can not be intelligently presented without picturing, briefly, social conditions as well as various problems concerning medicine and pharmacy at and preceding the date of their introduction. Nor can this story be fairly told, even at this late day, without many regrets, even though its various phases be handled in the most sympathetic manner.
Appalling is the record left in print concerning the cruelties and the crudities at that date practiced in the name of medicine. Pathetic is the recollection of the effects of the old-time standard medicines. The story is one and the same, whether the treatment be that of a strong man attacked by an acute trouble, undergoing a course of mercurial cathartics, bleeding, and cantharides blistering; of a tortured girl in the last stages of consumption, with breast a running sore from the tartar emetic plaster, or croton oil vesicant, applied by the physician; or the fever-parched, helpless child, confined in a hot, closed room, denied a breath of fresh air, vainly pleading for a spoonful of cold water or a bit of nourishing food. Alike the course of authoritative medicine and of primitive dosing, whether in Europe or America, consisted in cruelty piled on top of torture, of catharsis to physical depletion, of cupping blood through the skin, and the copious abstraction of much-needed life blood from the veins of a patient who had been starved to exhaustion, by direction of the man who blistered and bled and purged. Then, the step of the physician made the sick
man shudder. At the word medicine the child would cry in fear.

According to the medical theories largely prevalent in the Mediaeval past, diseases were to be considered not as departures from the normal, but as the effects of aggressive devils or evil spirits, to be driven out by fire and sword. The era had but recently passed when religious conceptions of supernatural influences by the powers above and below were connected with bodily ailments and afflictions.
Traditions that had traveled down the centuries bound men unaware of such subjection, to conceptions concerning disease difficult now to comprehend. Astrology and the influence of the planets, and the belief in the mysterious power of the number 13, is even to-day a study of

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men possessed of balanced education, whilst as late as the day of Culpepper the description of each plant was prefaced with the name of the planet that was supposed to dominate its action. Far back of it all, and yet influencing it all, is seen the age of imaginative conception, of poetic imagery, that constructed gods and goddesses, such as directed the affairs of men in the day of the glory of Olympus.
Natural, was it not, that out of this epoch of necromancy, superstition, and fantastic poesy, diseases should have been viewed as essences from without, sent by an omnipotent Creator or an antagonistic devil to torture the flesh of man? Nor could it be expected that an empirical art, linked with such as this, should have lost its traditions by being transplanted to America.

In the opinion of even authoritative practitioners of medicine of Colonial days, the devilish or spiteful intruders could no more be subjugated by kindness than could the Prince of Evil be subdued by friendship. But yet the man of medicine might not openly view them as devils or spirits of evil, and might resent such a reflection. But, whether the ideas of old prevailed or not, the methods of old yet lingered. Although the disgusting animal remedies once favored were neglected, the most poisonous of drugs were administered in heroic dose, or the method that was the most barbarous or disagreeable, was considered, even by conservative therapeutic authorities, including the most sympathetic physicians, at the date of the introduction of the “American Eclectic Concentrations” as the remedies most likely to serve the sufferer and to save life.

In view of these conditions, need any apology be made for the fact that the remedial agents of the first part of the last century were necessarily either nauseating and disgusting, or vicious, cruel, and in dosage too often deadly? Whosoever will study the records of the past will perceive, that, whilst poisonous drugs, nauseating doses, and
excruciating applications were authoritative favorites, the substances that produced the most pronounced shock were viewed with the greatest favor, even though they were directly followed by marked or even serious after-consequences, in some instances more terrible than the primary disease for which they were administered. Let any pharmacist or physician, of any school whatever, read the story of those days, as voiced in the authoritative medicaments and by the
treatment of licensed physicians, as well as that given in many works then standard, on Practice and Materia Medica, and consider how he would feel now, were he to attempt to practice his art under the

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limitations then rigorously enforced, or what would be his course were a loved one undergoing the ordeal. To place oneself in that critical attitude is to stand where stood the protestors against medical authority, in the beginning of the last century.

The Uprising.—In that day in America the dogmatism of intolerance dominated those in power, whether in politics, religion, or medicine, and possibly nowhere was the battle more fiercely fought than in the last-named field. The physician who discredited the prevailing methods, and who was courageous enough to voice his protest, was likely to be ostracized by many of his brethren, as a person tinctured with quackery and linked with charlatanism. Intelligent and educated laymen, protesting against the barbarisms to which their loved ones were being subjected in the name of authoritative medicine, were, as a rule, neither given a respectful hearing, nor recognized as entitled to any consideration whatever. The first great American “Trust” was that formulated in behalf of medicine, medication, and dogmatism such as this, though, be it said, its votaries believed their crusade to be in the direction of the suppression of quackery advocated by men incompetent to know what was needed in medicine. Out of it all came naturally a popular uprising against the methods of “Fashionable Doctors.” It was born of a wave of righteous indignation—not against individuals—but against cruelties almost universally practiced, and against fallacies that were apparent to all but those involved in their practice.

In that period also arose, of like necessity, the kindly European Homeopathic school, as an emphatic protest against all that was cruel and destructive. Even doubters of Hahnemann's theory believed that a peaceful, natural death was to be preferred to one of needless torture, and that it were better to take no medicine at all, and in a spirit of hopefulness allow nature a chance, than to follow the way of those who passed into the hands of such practitioners as the famous
English Dr. Lettsom (John Coakley), concerning whose methods a critic ventured to write:

I puke, I purge, I sweats 'em,
And if they die,-I Lettsom.

Into such times as these, and among such methods as then prevailed, came Wooster Beach, Samuel Thomson, John King, and other 1 At that date the letter “I” was often substituted for J.

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American reformers from both within and without the only authoritative school of medicine then existing, for no recognition had
as yet been given the followers of Hahnemann. Moved alike by the same cry of tortured loved ones that swept over America as it did over Europe, this conglomeration of dissenters united against a common enemy. During the first part of the nineteenth century these and such as they, educated and uneducated—many qualified by law to practice medicine, but the majority ignorant of the very principles of therapy—conducted their crusade against death-dealing medicines and the wrongs of a system of medication whose votaries so often considered the advocating of kindness to the sick as rebellion against lawful authority, and the application of humane methods to the suffering, as a crime against established science. 2 Throughout all America came this uprising of the people, no section being exempt.
From Massachusetts to Florida, from the Atlantic to the Mississippi, the rebellion raged. It was a combination of the unorganized, unprofessional majority, assisted by an inside, rebellious, selfsacrificing, professional minority. It was a home-to-home crusade, that needed no outside witnesses, no argument from afar, because in every American household pleaded the face of a tortured loved one, or lingered the memory of one who had failed to withstand the
physician's inhuman ordeal.

Thus it was that, powerless to effect reformation within the ranks, men of learning, as well as the common people, formed their “societies” in the great outside, their object being alike to serve humanity and, as they also hoped, the cause of medicine. This latter object could be attained only by discovering better, and milder, remedies than those transplanted from abroad, to be employed by somewhat similar but yet more kindly methods.

2 It must not be forgotten that this crusade in behalf of the people was favored by a large number of physicians and many authorities of the dominant school, for among the most aggressive of the protestors were numbered many physicians who rebelled against the barbarisms then prevalent in medicine. Not all medical authorities were content to accept the dogmatism of that date. Read the Collections of B. S. Barton, M. D. (Lloyd Library Bulletin No. I) or Zollickoffer's Materia Medica, or Tully's great two-volume treatise, or even Thacher's Dispensatory, to perceive that the dissenters had earnest co-laborers within the medical trust.
See also Lloyd Library Bulletin No. II. Read the letters of the talented Professor Waterhouse, M. D., of Harvard University. Remember that Wooster Beach was a graduate of the Medical Department of the University of New York, and John King was an educated man of many languages, a lecturer on such scientific subjects as geology, magnetism, astronomy, and physiology in the Mechanics’ Institute of New York before he took part in the American crusade for better medicines and kindlier medication. But such facts as these did not prevent such men as these from being ostracized (by authority) as quacks and charlatans.

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With this in view, a great section, seeking a new materia medica, turned naturally to the development of American remedies of botanic origin. 3 The preparations employed were simple and compound syrups, tinctures, acetates, juices of plants both fresh and dried, as well as powders, infusions, and decoctions of substances generally fitted for domestic preparation. As a rule the dose was large, often distressingly nauseating, and in some cases barbarous, as judged by
the standards of the majority of physicians to-day, for even these “Reformers” could not, at the start, disenthrall themselves from the transplanted, Mediaeval, European medication fallacies and the methods that encompassed and entangled them. Cullen's Materia Medica and Practice, the Edinburgh and London Dispensatories, the works of Quincy and of the domestic European empiricists of that date were in many American households, and these, together with traditional precepts, could not but make an impression. Even those in rebellion against dominant methods too often imagined that a medicine, to be useful, must be disagreeable, and that the depleting action of both the cathartic and the emetic was a necessity, in the simplest ailment. The phantom of “disease devils” still lingered, and tinctured the methods even of the revolutionists. Thus it came that too many of the reform remedial substitutes., introduced to replace more barbarous remedial agents, were themselves viciously energetic, whilst the primitive surgery of those days is frightful to contemplate. Witness the treatment by his father (from which he barely escaped with his life) of that archrebel of them all, Samuel Thomson, in the case of a severely cut ankle.

I had the misfortune to cut my ankle very badly, which accident prevented me from doing any labor for a long time, and almost deprived me of life. The wound was a very bad one, as it split the joint and laid the bones entirely bare, so as to lose the juices of my ankle joint to such a degree as to reduce my strength very much. . . . My father, in dressing my wound, had drawn a string through between the heel-cord and bone, and another between that and the skin; so
that two-thirds of the way round my ankle was hollow.—Lloyd Library Bulletin,
No. II, pages 6 and 7.

No intelligent patient of to-day would tolerate either Samuel Thomson's heroic courses of lobelia medication or Beach's too

3. Talented men in authoritative positions also cherished hopes concerning the possibilities of the American Flora. The two Bartons, Thacher, Zollickoffer, even Dunglison, may be cited.
However, with the advent of the “Irregulars,” the “Botanics,” the “Indian Doctors,” and such, the “Regular” profession, strangely enough, relinquished their study of the American Flora and, yet more strangely, ostracized the intelligent outsider who was specializing in this line. In this they lost a mighty opportunity.

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frequently nauseating, botanic drug mixtures, nor would such systems be unflinchingly practiced to-day by an Eclectic or Thomsonian physician of repute, any more than would the Allopathic medicine and methods, then “Regular,” be followed now by the most orthodox in the ranks. But severe as were the methods of the reformers, they were soothing and kindly, as contrasted with the blistering, bleeding, purging, and vomiting of those practicing the imported, Mediaeval system of European medication. Largely for this reason “domestic” and “Irregular” medication became the hope of a great section of the American people.

The view presented, when from this distance the epoch is taken as a whole, is surely sufficient to enable one to comprehend much that the actors, involved in the passing along, could not perceive. A far reaching social revolution was in progress. One party believed in tradition and in authority, and held that progress must come from within, and not from without. The other party, perceiving only the wrong of methods established, as they believed, in error and
superstition, became hopeless of their correction by the men practicing those cruelties. It was a far-reaching uprising, in which a people more enlightened than formerly, more independent of authority than ever a people had been before, united in a rebellion, not against individuals, but conditions. It was a campaign of education, in which the side in power was organized, trained, and allpowerful; the other was heterogeneous, composed of the ignorant as well as people of education, who presumed, for love of humanity, to demand of authority that cruelty in behalf of tradition be abolished.
In this mighty uprising the alkaloids, resinoids, and such came into play, but were an incident only. They failed primarily, but yet served a mighty secondary purpose, for they hastened the day when Eclectic physicians and a great part of the dominant school should abandon heroic dosage as well as depleting medication. 4

Necessity for Concentrated Remedies.—The small doses of the mineral remedies, such as tartar emetic, calomel, corrosive sublimate, and the iodides, as well as the energetic organics, such as gamboge, opium, and others that the reform physicians were trying to replace with remedies more kindly in action and after-effect, were, by reason of their compactness, favorably contrasted with the large doses of such remedies as the syrups, tinctures, and crude powders, largely
4. Should the author presume, ever, to picture those times as he believes they should be pictured, a fund of curious extracts from past literature will prove available.

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employed as reform substitutes. This made it essential that, if possible, concentrated representatives of the American plants be evolved. The necessity for this may be best shown by a contribution from Dr. King to the Western Medical Reformer, 1846, pp. 175 and 176:

I have for a long time noticed an obstacle to the progress of Medical Reform, with a very numerous portion of the community, particularly those who, when ill, desire the least medicine possible to effect a cure, which, by the way, is not
a limited class. The obstacle is, the large doses and enormous quantities of medicine usually administered by those who practice with medical plants.
However, there is no actual necessity for this; our medicines are as capable of being prepared in diminished quantities as any other, and when thus reduced, are much more effectual in their results. Thus, Blue Flagroot (Iris Versicolor)
contains resin and mucilage; in the former reside its purgative and alterative properties, in the latter its diuretic. Then why administer the crude root in powder, in which these properties are combined with woody fiber and other inert substances, when a few grains of the proper constituents will answer? The same is, the case with the Cohosh root (Cimicifuga Racemosa); its alteratives, anti-scrofulous, anti-rheumatic, emmenagogue, and other properties for which
it is generally employed, reside in its resin.

For the last several years I have prepared my medicines, or, rather, those of which I make the most frequent use, in such a manner that the doses are much smaller in quantity than usual, and are fully as effectual in their results, if not more so, than are the same articles as generally administered. The object, particularly in chronic disease, is not to shock the system by repeated large quantities of active medicines, as is too much the case with practitioners, and from which cause very few real and permanent cures are effected in chronic cases,—but to give medicines in the least possible doses that may be found necessary to keep the system constantly under their peculiar alterative, tonic, or other action, and always in union with the other requisites of proper exercise, diet, cleanliness, etc.

This well recognized necessity of a more eligible pharmacy opened the door to the “Eclectic Concentrations.”

Discovery of Resin of Podophyllum the First “Eclectic Resinoid.”—In 1831 (Am. Jour. Pharm., 1832, pp. 273-275) William Hodgson, Jr., made an assay of podophyllin rhizome, employing, after the methods of that date, destructive chemical reagents and heroic processes. The products obtained were all decomposition results, and thus Mr. Hodgson, through the process of too much chemistry (as now a common fault in plant examinations), failed to

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discover the natural energetic resinous constituent, afterward so conspicuous. 5

In 1847 (Am. Jour. Pharm., 1847, pp. 165-172) Mr. John R. Lewis again investigated the rhizome, and again applied too much chemistry, the result being a series of decomposition products, among which was one of slight cathartic action, very slight, as contrasted with the now well-known and simply prepared resin, eight grains being the cathartic dose as reported by Mr. Lewis. No argument is necessary to show that the resin, if present at all in his substance, existed in minute amount. Many writers, probably copying from each other, have continued voicing the error that the resin of podophyllum was discovered by Hodgson (1831), and that his product was verified by Lewis (1847). This, however, is not an excuse for the long neglect shown the real discoverer, Dr. John King, whose process of manufacture and product, as described by him (1835 and 1844), have been official in the pharmacopeias of all countries since the drug's introduction.

In 1835, Dr. John King (then a young physician of the Botanic, or “Irregular,” School of Medicine), accidentally discovered, and then administered, the resin of podophyllum, which may be designated as the “resinoid fore-runner,” because it constituted the first American member of that list of substances. Its discovery, and the serious consequences following the blunder of its initial administration, can best be stated in the words of Professor King, which I have, by
authority, in his own handwriting:

NORTH BEND, OHIO, June 15, 1887. PROF. JOHN URI LLOYD.

My Dear Sir,—At your urgent request, I will endeavor to give you a brief account of the discovery of the Resin of Podophyllum Root, more commonly known as “Podophyllin.” My introduction to it was entirely accidental, and attended with very unpleasant circumstances.
                       In the fall of 1837, 6 1 think it was, knowing nothing of this resin, an attempt was made to prepare a hydro-alcoholic extract from some forty pounds of the coarsely-powdered Podophyllum Root. A portion of alcohol having been distilled over from the root tincture, water was added to the remaining

5. Mr. Hodgson has been referred to as the discoverer of the resin. We prefer to credit him with the first attempt at the assay of the root of podophyllum. The same is true of the examination made by Mr. Lewis. Neither of these investigators discovered the resin, neither of them pursued a process similiar to that ever employed in its production, and neither of them claimed to have discovered the now well known cathartic.
6 The date was 1835, see Philosophical journal and Transactions, 1844, VOL I pp. 157-166.

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tincture, the intention being to evaporate this diluted tincture that a hydroalcoholic extract might be had, but night coming on, the process of evaporation was postponed until the following day. On the next morning, while stirring the cold mixture, numerous pieces of a dark, somewhat porous and rather brittle body were found in the fluid. Many were the surmises as to what they were, and the query arose as to their value, if any, as a medicinal agent.

In the midst of these speculations, a young lady, about seventeen years of age, who was present, complained of feeling ill. Having no idea of the intense activity of the article just discovered, I administered about twelve or fifteen grains. Nothing further was thought of the matter until about an hour afterward, when my attention was called to her condition. She was in severe pain and distress, cramps in the stomach and extremities, pulse small and feeble, extremities cold, excessive vomiting and hypercatharsis, and apparently sinking rapidly. Her condition greatly resembled that of a person suffering from a fatal attack of Asiatic cholera. To say that I was greatly alarmed would but feebly describe my mental condition. I ran to secure the aid of two or three professional friends, but could find none of them in their offices. Then I ran back again, trembling over what might be the consequences, and thinking out a course of treatment to pursue. A princely fortune could not induce me to undergo a repetition of such condition.

By the time I reached the patient, I had become more calm. A half saturated, aqueous solution of potash saleratus was given, in tablespoonful doses, every ten minutes, several doses being administered before the stomach would retain it; subsequently, the intervals between the doses were lengthened.
Sinapisms were applied to the wrists and ankles; a fomentation of bitter herbs, as hot as could be borne, was applied over the stomach and abdomen, changing it as often as required. In about an hour the extremities became warm, and a general perspiration soon followed, with diminishing suffering and a partial return to a feeling of health and strength. In about an hour or two succeeding the improvement, the sinapisms were removed, an infusion of slippery-elm bark was ordered to be drunk freely, and about eight grains of the Compound Powder of Ipecacuanha and Opium were given every three hours. The next morning she was decidedly better.

In the course of the second day her friends allowed her to have a little soup, which was followed by a serious gastro-enteritic inflammation. The fomentations and sinapisms were repeated, and the Diaphoretic Powders continued, as well as the slippery elm infusion, to which some prepared charcoal was added, not daring to prescribe a more active laxative. By perseverance in this course, the patient recovered in six or seven days, but, unfortunately, with some chronic gastro-enteritic abnormal condition, that remained for many years. From this experience I was so influenced that I feared to use any of the remainder of the resin until at least eighteen months had passed, when I ventured a repetition of its use, but in much smaller quantity, and with most excellent results.

There, my dear Professor, you have in a nutshell my discovery, which led to further investigations, resulting in the obtainment of more or less active principles from other of our medicinal plants.

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In closing, permit me to add that I have found your medicinal preparations, resinoids, concentrated remedies, etc., that I have had from you since you have entered into the manufacture, to be reliable and worthy of confidence.
                   
           Yours with Respect,

JOHN KING, M. D.

The alkaloids quinine and morphine, and the energetic resin of jalap, had but recently been established in authoritative practice as the pioneers of a new class of ultimates in plant products. These, evolved abroad from drugs of foreign origin, were naturally welcomed by the dominant school, which closely affiliated with all that came from Europe, and being energetic in small doses, they served well the heroics in practice. But it remained for Dr. King to take the first step in the direction of a similar class of American ultimates. At first Dr. King's experiments promised brilliant results. The energetic resin of macrotys 7 (cimicifuga) was quickly followed by the resins and oleoresins of iris, black cohosh, leptandra, and others. To his mind came then, naturally, the question as to why the major part of the American materia medica in use by the “Reformers” might not yield ultimates, many of them equally valuable, which in minute amounts
would parallel the large doses of their respective crude drugs. Great was his enthusiasm in this work, greater was it in behalf of improved methods for curing disease by means of small doses of palatable medicines. Little, however, did he imagine, in the enthusiasm of his discoveries, that his own hand, in a day to come, was destined to deal the most crushing blow to these same products, when, by their indiscreet use and by reason of the commercial methods that were
applied in their direction, they had all but wrecked the cause of Eclecticism, to which he had devoted his life work.

The original method of making the Resin of Podophyllum, as given by Dr. King in the Medical Reformer, was as follows:

I obtain only the resin, by extracting all that alcohol will take up, then filter the alcoholic tincture, to which I add an equal amount of water, and separate the alcohol by' distillation—the resin sinks in the water.—Western Medical
Reformer, 1846, p. 176.

This process, without materially8 altering the product, was

7. Discovered by King shortly after the Resin of Podophyllum.
8. This word is used necessarily. The resin made by King's original process is cleaner, and more energetic, than the resin made by the official process. This results mainly from the dilution of the extract (tincture) at the time of precipitation by the water. This permits the resin to fall in a state of very fine division, each particle being well washed of extractive matter by the water.

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afterwards improved by evaporating the alcoholic tincture to a cream, pouring it into cold water, and collecting the precipitated resin. This resin stands to-day, as then, typical of the cathartic side of podophyllum, but it is yet not a representative of all that lies in podophyllum. 9 Nor is Resin of Podophyllum an isolated unity. It is a complicated educt from podophyllum, although all attempts to obtain from it a decomposition product or a fragment as comprehensively useful as the crude resin have as yet failed, and are likely to continue failures. The products made from it are but
fragments of that “resin,” which, in itself, paradoxical as it may seem in the light of past criticism of the word “podophyllin,” is not a true resin.

Concerning the Name Podophyllin and the Class it Headed.— Among those who advocated the name “Resin of Podophyllum,” was its discoverer, Professor John King, to whom thus belongs not only the honor of discovering this substance, but of giving it the name “Resin of Podophyllum.” In its introduction he employed this term, but finally, reluctantly, accepted the popular name “Podophyllin,” making this the prominent name in the first edition of the American Eclectic Dispensatory (1852), though he supplemented it by calling the drug “a resin, to which the name of Podophyllin has been given.”

Although the name podophyllin was attacked by Dr. Squibb and Professor Procter (see Am. Jour. Pharm., 1868, p. 1), the late Mr. William S. Merrell, of Cincinnati, who first (1847) prepared the crude, resin-like precipitate for commerce, and who first used the term podophyllin, strenuously and ably defended that name. In reply to critics, he called attention (Eclectic Medical Journal, July, 1850, p. 299) to the fact that the names for jalapin (then established in “Regular” literature), and several other like bodies which were not definite chemical compounds, were devised after that plan, and he finally informed his antagonists, who became personal in criticism, that the name podophyllin had not originated with him, but that he had, in reality, accepted it at the suggestion (to use his words) of “Professor Wood, the author of the United States Dispensatory, who is no mean authority.”10 Mr. Merrell then continued his argument by

9. Scudder's Alterative, yet a favorite remedy with many physicians, was designed to exclude the cathartic resin and to utilize the tonic constituents of this drug. See Am. Disp., 1866, and subsequent editions. Within the last year Dr. N. M. Dewees, of Cambridge, Ohio, has also introduced an Elixir of Podophyllum, long in use in his practice, that is very pleasant, very effective, and yet in its acknowledged excellence, is dominated by the other podophyllum structures rather than by the drastic resin.
10. See P. 27

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saying:
The names of the resinous principles, or resinoids, should be made to terminate in in, after the analogy of the generic substance resin or rosin, and accordingly we should write Podophyllin, Macrotin, Jalapin, etc.—Eclectic Medical Journal., 1850.

This method of nomenclature was accepted by Hill (Cincinnati) and Keith (New York), as well as by other makers of Eclectic remedies of that period, who placed a limited line of “resinoids” upon the market.
They accepted, without question, the nomenclature that Mr. Merrell had suggested, although, in Eclectic literature, some very acrimonious discussions appeared concerning the drugs to which the names were applied. As before remarked, when the precipitate, more or less resinous, obtained from podophyllum peltatum, finally demanded recognition in the United States pharmacopoeia, it came before the revisers of that work as an Eclectic drug, but under a name formulated by the editors of the United States Dispensatory, a fact overlooked by some persons antagonistic to Eclecticism, who opposed that name, thinking it an Eclectic term.

The substance under consideration was, as before stated., the first member in the list of Eclectic “resinoids,” alkaloids, and concentrations to attain popularity. Through the influence of Professors King, Hill, Morrow, and other contributors to Eclectic literature, as well as by reports of practitioners who used it, “podophyllin” quickly assumed a position and importance seldom attained within so short a period by vegetable remedies. Its unquestioned efficacy as a cholagogue cathartic—in that day of cathartic supremacy established it in the practice of others as well as the Eclectic profession. Appearing in the heat of a celebrated controversy over the abuse of the mercurial preparations then so extensively employed in Regular practice, it was hailed by Eclectics as a vegetable substitute for the mercurials, and was called by them the “Eclectic Calomel. 11 ”

Before its character was understood by the leaders in the Regular school of medicine, it became, under the name podophyllin, perhaps the most prominent of Eclectic drugs. Such conspicuity could not exist, however, with reference to a drug used so extensively in Eclecticism, without recurring introductions to members of the

11. These discussions, being confined to Eclectic publications, are unknown to most persons of the Regular" school, for few have that literature at hand.

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Regular school and in consequence, long before it was authoritatively recognized by any of their book-makers, it came into general repute With numbers of their general practitioners. Thus commercial “Phodophyllin” became a valued drug in general Regular practice, years before it received recognition either in the United States Pharmacopoeia or Dispensatory. Hence it was that, when at last it was deemed advisable to give a position in the Pharmacopoeia to this
drug which had long been known to be of unquestioned value, it was found that Mr. Merrell's name, Phodophyllin, had become commercially and professionally established, at home and abroad.

Probably from ignorance of its record in Eclecticism, at least without recognition of that fact, the controversy over the name was now resuscitated, and was acrimoniously continued, when the drug knocked at the door of the U. S. P. As early, however, as 1851 (see Am. Jour. Pharm., 1868, p. 1), the late Edward Parrish had recognized the advent of these products of Eclectic pharmacy (resinoids or concentrations), and deprecated their names. He said,

As well might the Ellis' Calisaya Extract be called quinia, as the impure resinoid substance precipitated from a tincture of May-apple, by the above process, podophyllin.

This argument, however, failed to impress either the makers or the consumers of “Podophyllin,” and even when the preparation became official in the United States Pharmacopoeia (1860) as “Resina Podophylli,” the title of the commercial drug remained unchanged.
This fact was commented upon by Dr. Squibb in 1868, who considered it “unfortunate that those whose aim should be to give accuracy and precision to matters connected with medical science and art, should so commonly refuse to this substance its proper and correct name, and adhere to the inaccurate and otherwise objectionable name of ‘Podophyllin.’” He severely criticised the names affixed to the class (the Resinoids or Concentrations), of which
podophyllin was a member, stating that the termination in was—:

applied to this and other substances by the Eclectics, through ignorance of its true nature. It is a resin proper,

he continued,

and there seems no good reason for miscalling it by an incorrect name which has attained an equivocal popularity, and the common pronunciation of which

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is so vulgar and inelegant. 12

Notwithstanding this criticism, supported indirectly by the writings of other talented and enthusiastic leaders in Regular medicine and in pharmacy, who confined themselves to the official appellation and threw their influence in the direction of the name that was asserted as being the only scientific and proper one, little impression seems to have been made on either those who manufactured or who consumed the drug. The United States Pharmacopoeia, in each subsequent revision , has made the name “Resina Podophylli” (first given to it by Professor King), official; the influence of the majority of instructors has been continuously added thereto. But to this day, in commerce, when the drug is specified, and usually when it is prescribed by physicians, the appellation is Podophyllin.

Had the advice of Dr. King been taken, the definite resins would alone have been called resins;13 the oleo-resins would have been called oleo-resins, with names terminative in in; and the alkaloids would have been called alkaloids (names terminating with the syllable “ine,” or “ia”) ;14 whilst dried extracts would have been called extracts, dried. But the care of Dr. King and his systematic co-laborers was not effectual in controlling either the nomenclature or the composition of the many incongruous substances that, in rapid succession, between 1847 and 186o, were, by manufacturers of plant preparations, thrown on the American drug market under the titles “Alkaloids” and “Resinoids.”

Enlarged Use of the Termination in.—Closely following the commercial introduction of the “Resin of Podophyllum,” under the condensed name “Podophyllin,” and eleven years after King had established its energetic cathartic nature, came, as already stated, the introduction of many other substances, some of similar resinous natures, others markedly different. Among the most typical of the resins, and once conspicuous by reason of the hope that it might carry the cathartic and other qualities of the crude drug from which it

12. It has since been shown that podophyllin is not a resin, nor yet a simple substance, It carries more than one body, and is partly soluble in water.
13. Substances thrown from alcoholic percolates by water. They were seldom, if ever, true resins, but no better nomenclature is even now possible.
14. The tendency at that date, in both commerce and the profession, was toward single names, usually terminating with “in” or “ia,” as applied to the energetic compounds obtained from drugs. The termination ia was applied to organic bases of alkaloids, of which Morphia and Quinia may be cited as examples. King, as was true of others at that date, thus used ia as an alkaloidal termination.

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was evolved, was that derived from Leptandra virginica.15 This, as finally established and used by King, was a dried hydro-alcoholic extract, and by manufacturers was called Leptandrin. Concerning it, in reply to a question, Dr. King (1880) wrote as follows:













































15. Dr. King, its discoverer , subsequently demonstrated that this resin was practically inert. This, to him, was a deep disappointment.

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August 6, 1880.

Prof. John Uri Lloyd,

Dear Sir,—In reply to your request, desiring me to give you a statement concerning the origin of the article designated by the term Leptandrin, I will observe that in the year 1840 I first prepared an extract from the Leptandra virginica root, by forming an alcoholic tincture, and an aqueous infusion subsequently; these I evaporated separately to dryness, pulverized them and mixed them together. In the Western Medical Reformer of April, 1846, published at Cincinnati, pages 175 to 178, will be found a communication relative to the subject, in which paper I also called attention to the resins of Blue Flag, Black Cohosh, Podophyllum, etc., as well as to preparations of several medicinal agents. Previous to this communication these resins and preparations were unknown to pharmacists and physicians; and it was a year or so subsequently before any pharmacist ventured to prepare them for the medical profession. But I would remark here, that in 1844, in another journal, I had called attention to the resins above referred to, which, however, attracted but little notice. I know of no earlier publication concerning these remedies, but as in such matters dates give priority, should such publications be found, my claims will become valueless. As to the nomenclature given to these resins and dried extracts, it did not originate with me.

Yours truly,
John Ming, M. D.

Let us emphasize the manner in which Dr. King disclaims responsibility for the word leptandrin by repeating from his letter the sentence

concerning the origin of the “article designated by the term Leptandrin!”

Note, also, his dignified criticism of the terminology employed, in the final sentence of the same communication:

As to the nomenclature given to these resins and dried extracts, it did not originate with me.

At that date Dr. Alexander Wilder was in the zenith of his mentality, and was deeply concerned in the reform movement in medicine. Like Dr. King, he felt the odium of the alkaloidal-resinoidal octopus that had so unexpectedly wrapped its tentacles about Eclecticism, and he too protested against the imposition. From a letter to us, November 6, 1905, we extract as follows:

I used to plead against the (illogical) naming of the resins “podophyllin,”

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“macrotin,” “leptandrin.” I was willing to use these terms as adjectives, but what little chemistry I possessed convinced me that they were neither principles, proximate principles, nor even concentrations.

Notwithstanding these facts, and notwithstanding the fact that an in compound would probably be confused with the termination ine, already established in alkaloidal chemistry (as in morphine and quinine), the cumbersome, technical terms of precise science gave way to commercial expediency (as is yet necessarily the case in similar problems), and the terse and attractive names 16 that appealed to both the professions and the trade, became firmly established. 17
Yet, although Professor John King came finally to tolerate the innovation, whenever a substance was, to his knowledge, simply a dried solid extract, whether aqueous, alcoholic, or hydro-alcoholic, he insisted on the proper designation. For example, note how, in the following articles, over half a century ago, he differentiated between the resinous substances podophyllin (resin), iridin (oleo-resin), and the dried, hydro-alcoholic extract of zanthoxylum fraxineum:

I know of no better sialagogue than a mixture composed of equal parts of Podophyllin, Iridin, and the dried hydro-alcoholic extract of Xanthoxylum Fraxineum; of which half-grain doses must be given and repeated every two or
three hours. I recommend this as an officinal Eclectic formula for all cases where salivation is deemed necessary; also as an unrivaled alterative in many forms of chronic disease.—Eclectic Medical Journal, February, 1849.

Rapid now were the movements of the “resinoid, alkaloid” makers. Within a brief period, between 1850 and 1855, several manufacturers of medicine were rivaling each other in their efforts to establish both priority and superiority for their special makes of the respective resinoids, concentrations, and alkaloids.

Nor were the united efforts of King and others earnestly concerned in Eclectic therapy and reform medicine capable of preventing, or for a time, even, modifying the marvelous and too often unfounded claims made in behalf of the therapeutic virtues of the so-called active principles. A resinoid craze arose, similar to other professional distempers and fanaticisms, such as the American elixir craze of the early seventies, and similar fads that from time to time have risen to

16. Formed by affixing the termination in to the (abbreviated) names of the plants; examples: macrotys, macrotin; leptandra, leptandrin; etc.
17. Scientific terms are often too ponderous for either professional men or men in commerce to
use in the affairs of life. Concentration, compactness, easy movement is essential to success of
a title. Even the professional Ipecacuhana became of necessity corrupted into Ipecac.

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plague over-zealous enthusiasts. 18

Having now briefly given a history of the discovery of the concentrations, and the application of the term in to the resin of podophyllum and similar substances, let us next consider the

Introduction of the Commercial “Concentrated” Principles or Resinoids.— Professor King was a personal acquaintance, a correspondent, and an admirer of the talented Professor Tully, of Yale University. Immediately after discovering the resin of podophyllum, he communicated the process, together with his experience as regards its violent energy, to that exceptional authority, who, although an Allopathic physician, was both very liberal and very enthusiastic in his views concerning the ideals and efforts of the independent American reform investigators. Professor Tully called Dr. King's attention to the plant macrotys,19 and in 1835 King obtained its resin (macrotin or cimicifugin), after his previous method of making resin of podophyllum. Soon thereafter, 1840, he made and recorded the production of the resinous principles of iris versicolor, aletris, and leptandra. The last substance, although more of a resin

18. Let it no, be understood that we would presume to condemn the efforts made by experienced, self-sacrificing, earnest men, who, with the object of bettering conditions, involve themselves in what will surely be referred to, in a future day, as heinous fallacies or grotesque fantasies. Their efforts show that they too well appreciate the fact that conditions about them need bettering. Nor would it be just to ourselves to permit any one to presume that we believe such fallacies are necessarily fruitless. Probably each comet that streaks the sky leaves a bit of dust that somewhere, some time, becomes useful. The injection of sulphuretted hydrogen, per rectum, as a cure for consumption, led men to question the infallibility of some authorities, who spoke “by authority,” made so by position. The cruel vivisection methods of present investigation are leading men involved in other long established barbarisms to abandon their
systems of medication. Dr. Osler, as a heretic, had cause for his heresy, even though he outclasses some “Irregulars” in his questionings of old-time medicines and methods once considered the only scientifically “Regular.” Even the blue-glass theorist led many physicians to think of sunlight as a remedial agent. The Rochester (New York) State Hospital is now (1909) instituting a “sun room,” described by the Rochester Democrat and Chronicle as follows:
“Extensive improvements are under way at the State Hospital which will add to this very large State institution for the insane a number of conveniences. A sun room is under construction adjoining the building in which some of the special cases are confined. At present these patients are confined within brick buildings not of the modern type. The new building will be fifty-three feet in length, twenty feet in width, and two stories in height. The roof will be of slate, but the sides will be of glass, allowing the rays of the sun to enter from the east and south.
Galleries will be constructed, so that the patients will be able to get sun baths without being given undue liberty.”—Dem. and Chron., July 22, 1909.
19. Eclectic physicians have always used the term macrotys in preference to cimicifuga. (See Lloyd Brothers' Drug Treatise No. XIII, P. 3.) The name macrotys under Eaton's authority, and Rafinesque's precedent, had become established in early American botany. Eclectics do not believe in changing the name of a remedy every time a botanist alters the name of a plant for some reason, personal, fanciful, or discursively proper or improper. Hence in Eclectic literature, the name mac. rotys still has precedence.

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than is resin of podophyllum, did not carry the therapeutic qualities of the drug, proving to be practically inert. For this reason it was subsequently replaced by the dried extract of leptandra, under the name leptandrin. The same was also true of the resin of hydrastis, a plant that contains an abundance of resin and was one of Dr. King's remedial favorites, but which failed to give an active, resinous product. These exceptions to the rule which had produced the energetic resins of jalap, podophyllum, and macrotys were exceedingly disappointing to the men who hoped to evolve a line of
similar active principles from all plants. However, the various resinous, alkaloidal and extractive substances under the termination in, followed successively as commercial products, and within a few years Dr. King, as a means of introductory classification, very reluctantly referred to them under the blanket title “Concentrated Principles.” This is shown, 1849, by the closing sentence in his article, titled “Important Remedies,” as follows:

As the action of the concentrated principles of our remedies is now undergoing investigation, I would refer to the communication named in the commencement of this article20 for a list of preparations worthy of immediate notice, and will mention several which I have made and used, as particularly deserving the confidence of physicians. Dried hydro-alcoholic extracts of Baptisia tinctoria, Euphorbia, Ipecac, Hydrastis Canadensis, Phytolacca decandra, Cornus sericea, Rumex crispus, and Apocynum Cannabinum.—
Eclectic Medical Journal, 1849, p. 63.

Be it observed that these concentrated principles were by Dr. King called dried hydro-alcoholic extracts, and also that the list does not include any drug dominated by a poisonous or active resin or oleoresin. Notwithstanding criticisms and unfounded statements to the contrary, it is seen that, at that early date, the very opening of the American Materia Medica, Dr. King had instituted an intelligent classification of these substances, that should not have been neglected.

Under his classification, no blanket title would have been necessary. Had it been adopted, the so-called alkaloids, concentrations, or resinoids, that plagued Eclectic pharmacy in succeeding years, would have been unknown.
But, as shown in the historical section of this Bulletin, the care of Dr. King was not effectual in controlling either the nomenclature or the 20 Eclectic Medical Journal, 1846, April, p. 165.

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composition of the many incongruous substances that, in rapid succession, were thrown upon the American drug market under the names alkaloid and resinoid. Nor was it possible to resist the marvelous claims made for their therapeutical virtues. Within a brief period several manufacturers of medicines were rivaling each other in their efforts to establish for their respective make of the “Resinoids,” “Concentrations,” and “Alkaloids” both priority and superiority.

In this turmoil Dr. King and other Eclectics were most unfortunately and unhappily embroiled, and that, too, not without reason, from the fact that Dr. King had introduced the resin of podophyllum and others similar. This, added to the fact that these popular “Eclectic Remedies” were making inroads on medicines from abroad, 21 led professional antagonists and those connected with foreign drug affairs, together with men who did not care for fact or were not inclined to investigate, as well as those who believed that independent investigation should at all costs be prevented, to attempt to saddle upon King the whole heterogeneous mass of conglomerates grouped under the name “Concentrations,” and thus to discredit him and suppress the “Reformers.” As a result of this, men who did not read carefully or who were unacquainted with either King or his ideals, or were prejudiced beyond reason, were led to blame him for what others, over whom he had no control, and whose methods were directly opposed to his, were doing. A bitter ending it was to the
hopeful dream of that self-sacrificing philanthropist and scholar!

Concerning this phase of the subject, Dr. Alexander Wilder wrote us as follows:

So far as the exploiting of “Concentrated Remedies” and the whole array of these peculiar extracts is concerned, the endeavor to throw a responsibility on Dr. John King, beyond the three preparations known as Podophyllin, Macrotin, or Irisin, is without warrant. Dr. King was too careful to go faster in such matters than he felt that his footing would be safe. He was simply an expositor of the few substances that he had discovered, and had neither disposition nor interest in foisting upon the confidence of his medical brethren, or the public generally, a large number of the “new remedies” that he had neither discovered nor tested.

Can the dilemma of Dr. King be more forcibly emphasized than by

21. This commercial phase of the problem must not be overlooked. Europe supplied jalap and resin of jalap (coming from Mexico to London, thence to America); calomel at that time was imported from England, as were Spanish flies through London. These and such as these were being rapidly displaced by the new remedies.

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quoting his own words of protest against the imposition of the socalled Eclectic alkaloids, resinoids, and concentrations, written in the very height of the enthusiasm that had arisen in the Eclectic school in their behalf ?

Concentrated medicines: I have been accused of unjustly opposing these remedies, and discrediting them to the profession. I confess to having opposed the principle that all the agents of our indigenous materia medica would yield
their virtues in the form of a powder, and I still continue in the same belief.
—Dr. John King, editorial in the Eclectic Medical Journal, Vol. XXI, p. 96, 1862.

To this may aptly be added the far-reaching paragraphs of Dr. King in the Preface (pages 9 and 11) to the American Dispensatory, 1870:

The only point to be regretted is that many worthless so-called “concentrated preparations” have been presented to the profession, purporting to be those of American Medical Reformers, and which have been gotten up by either ignorant
or unprincipled parties, for the sole purpose of realizing wealth. The failure of these worthless articles to effect beneficial results in the treatment of disease might lead many to reject even those of value; which consideration alone has elicited the above remarks. . . . It is well known that many of these preparations, from which the manufacturers have, in some instances, already realized immense wealth, are valueless, or nearly so, while others again are downright impositions; for what chemist can believe in the reduction, for instance, of an active medicinal oil to the condition of a powder, without having its medical power more or less destroyed by the process for such reduction, even were the operation a mere trituration of the oil with some absorbent powder?

COMMERCIAL HISTORY OF CONCENTRATED REMEDIES.

Dr. Isaac Jacobs, of Bangor, Maine, was, so far as I can determine, the first to attempt the obtaining of vegetable remedies in concentrated form, becoming widely celebrated for his peculiar methods as early as 1835, the year King
discovered resin of podophyllum. He expended many hundred dollars in perfecting processes, and in making machinery for expressing and concentrating juices from plants. He contended that many medicinal plants lose their remedial virtue by the application of artificial heat, whereas sun evaporation afforded a superior product. He accepted that his success as a practitioner was due largely to these concentrated medicine.—Condensed from
a letter of Dr. Alex. Wilder Dec. 1, 1902.

These “Concentrations” of Dr. Jacobs, which antedated the commercial lists by sixteen years, were not the remedies sold in

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powdered form after Dr. King's discovery of the resin podophyllum, but compressed sun-dried extracts, or pillular extracts. They, however, directly anticipated the trade alkaloids and concentrations, of which the true resins were legitimate forerunners.

In 1847, (twelve years after its discovery by King), Mr. Wm. S. Merrell (see pages 24-30) made the first resin of podophyllum for commerce, and to him is due the credit of its first preparation on a manufacturing scale and its commercial introduction. This is irrevocably established, not alone from the fact that Dr. King gave to us, personally, the detailed circumstances,22 but because a record was made of the incident by King, in the first edition (1852), of the
American Dispensatory, as follows:

The credit of first preparing podophyllin, and other concentrated preparations, for the use of the profession generally, it being part of his vocation, belongs to Mr. Wm. S. Merrell, druggist and chemist, of Cincinnati, who first manufactured it, in June, 1847; since which time it has become an indispensable and highly important Eclectic remedy; and is likewise used by Allopaths and Homeopaths, and by the former, in all instances where they have employed it, it is preferable to mercurials.—Dr. King, in Eclectic Dispensatory, 1852, P. 314.

The first concentrations introduced to commerce were the resins of podophyllum, macrotys, and leptandra, and for some time these comprised the entire list.

Four years after Mr. Merrell (1847) introduced the resin of podophyllum to commerce, and after the typical “resinoids” had become well known to Western Eclectics, Dr. Wm. Elmer, of Auburn, New York 1851, went to Syracuse, N. Y., and formed a partnership with Dr. S. H. Potter, who had just established the “Syracuse Medical College.” There he associated with himself Dr. John T. Goodin, of Utica, New York, Dr. Dwight Russell, Dr. Sears Crosby, and Dr. Alexander Wilder, the project being, in Dr. Wilder's words (private letter):

“To open the American College of Pharmacy, which, however, was merely a pretext for an alkaloid, resinoid, concentration, business scheme.”

22. Dr. King related to me the incident as follows: “I went into the pharmacy of Wm. S. Merrell one, day after lecturing to my class, and Mr. Merrell brought to me a small amount of the powdered resin of podophyllum, saying, ‘I have made this according to the process you gave me; how does it compare with that made by you?’ ‘Exactly like that I made,’ was my reply. Mr. Merrell then gave samples to physicians, and introducted it to the trade.”

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Wilder further states:

This “College of Pharmacy” went on some months manufacturing podophyllin, macrotin, and leptandrin until midsummer, when it collapsed.

It began to manufacture in April, 1851, and sold out in the following summer to Hosea Winchester, 108 John Street, who moved to New York and continued the business as a retail drug store. Dr. Elmer., it seems, though the founder, took no active part in the college. On some “unsatisfactory pretext,” (Wilder) he withdrew in early spring, and removed to New York, where, in Bleecker Street, he formed a partnership with Mr. B. Keith, of New Hampshire, under the title Keith
and Elmer, the object being to engage in the manufacture of Concentrated Remedies., 23 which, according to Wilder, were simply dried extracts. Wilder writes:

The products appear to have been made in one uniform manner, by tincturing the drug with alcohol, and drying the product. 24

The new firm now employed as chemist a man named Grover Coe, 25 who continued with the firm of B. Keith after Elmer withdrew. About the close of the Civil War the firm moved to Liberty Street, but in the meantime, Grover Coe, like Dr. Elmer, had vanished, leaving no record other than his book. 26

Other medicine manufacturers now perceived in “Alkaloids and Concentrations” a new field. Dr. Hosea Winchester, of Missouri, opened business on John Street, having taken in Dr. Elmer, of Syracuse. In the West, several parties began successively the manufacture of the "Resinoids.,” “Alkaloids,” and “Concentrations,” the foundation for all these substances being the resins and oleoresins discovered by Dr. King, who published his processes, but, being a physician and scientist, and having no connection with any business concern (see pp. 8-10), never made any products for commerce.

23. This data is from a personal letter from Dr. Wilder. See biographical sketch. This firm, (Keith and Elmer), was the Eastern pioneer in the manufacture and distribution of the class of substances listed as “Concentrated Remedies.” “The business is now (1909) conducted by a son of B. Keith, 31 Park Row, New York City.” In this connection we will add, this Keith family is one of the old New England founders, active in early colonial days.
24. Such extracts are often oleo-resinous, and will not dry without the aid of an absorbing powder. This explains the presence of starch and other products found in them by Prof. Wayne.
25. Dr. Wilder tells us he was not a physician, although he used the title M. D., and was referred to in print as Dr. Grover Coe.
26. Biographical note, opposite portrait of Grover Coe.

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Soon active competition uprose. Keith became prominent as the Eastern “Alkaloid, Resinoid, Concentration” manufacturer, and was attacked by the Western interests. His friends, in turn, were not less aggressive in his behalf. Thus came many lines of products from many sources, all being classed either as alkaloids, resins., resinoids, oleo-resins, or as concentrations. Heralded were they as very concentrated remedies,, capable, in small amount, of producing marvelous therapeutic results. But, in substance, though bearing the same names, they were as different from one another as were the different makers' labels. Their common origin, based upon Dr. King's discoveries, naturally drew Eclectics into the controversy, a condition of affairs strengthened by the fact that Grover Coe was Secretary (1857) of the National Eclectic Medical Association, and that Dr. R. S. Newton, (at the start one of Keith's adherents), as well as others prominent in their advocacy of Keith, were aggressive Eclectics.
However, according to Dr. Wilder, Keith soon withdrew from all Eclectic and Thomsonian affiliations and complications, his remedies being used mostly by the dominant school, which school after a time (and the same is yet true), consumed most of the products. This reversal of conditions was owing, largely, to the crusade of King, Scudder, and others against heroic drugs, poisonous dosage, and especially the alkaloidal medication theories, which led Eclectics to abandon the use of most items of the entire class. Notwithstanding these facts, the “odium” of it all, and the imposition of it all, still clung to Eclecticism.

MANUFACTURERS OF THAT DATE.

The principal manufacturing firms of these substances, between 1851 and 1859, are recorded as follows: 27

F. D. Hill & Co., Cincinnati, 1852. “From a continued series of experiments, we. have no hesitancy in saying that by the improvements made in the mode of preparing the following list of Concentrated Medicines, we can offer these preparations to the public, containing all the medical virtues possible to be obtained from the different native substances, and of a finer quality than ever before manufactured.”

27. Some of these firms prepared concentrations, such as the true resins, etc., for a greater or less period before the list was advertised as a class. Others did not publish a list until some time following the use of the typical resins. For example, although Mr. Wm. S. Merrell introduced the first specimens to the trade, Keith was perhaps the first to make them a commercial feature. We include quotations from the text of some of the prices current.

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LISTS Podophyllin, Leptandrin, Macrotin, Myricin, Sanguinarin, Hydrastin. “This article, (Hydrastin), introduced by us (in 1851), is one of the finest extant among Botanic Medicines. In fact, it is the QUININE OF AMERICA.” To this list was added, in 1856, Caulophyllin, Cornin, Geranin, and Prunin.

American Chemical Institute, B. Keith & Co., 1854. “The object of this Institute is to prepare the active principles of indigenous and foreign medical Plants.” “One great and principal objection to the use of many vegetable remedies has been that it required such large doses of the article in a crude state, to accomplish the desired effect, that the bulk alone would defeat the entire purpose for which the remedy was administered.” Then follows a list of thirty-one “Concentrations,” the special claim being that they were in the form of powders.

Union Drug Store, Vine and Pearl Sts., (W. S. Merrell & Co.), Cincinnati, 1854. “The Resinoid and other Active Principles of our native plants are of a quality unsurpassed, if not unequaled, by others who have engaged in their
manufacture.”

Wm. H. Baker & Co., St. Louis, 1854. “New Concentrated Medicines.” “Their uses, doses, etc., together with a manual on Resinoids, will be mailed free to those who desire it.”

T. C. Thorpe,28 Cincinnati, (Court and Plum Streets), 1854- “Manufactures and keeps constantly on hand all the Concentrated Agents peculiar to the Eclectic Practice.”

Dr. I. Wilson, Cincinnati, 1854, “dealer in Essential Oils, Gums, Extracts, and CONCENTRATED PREPARATIONS.” (No list published.)

Tilden & Co., New York, 1856. “Concentrated Preparations, Resinoids, or Oleo-
Resins. We add to our own list some of the most important articles of this
class of preparations, and shall extend the number as fast as we are able to do
so, to embrace all that may be deemed of importance to the practitioners.”

LISTS Asclepin, Cimicifugin, or Macrotin, Cypripedin, Geranin, Hydrastin, Leptandrin, Podophyllin, Sanguinarin, Senecin, Scutellarin, Stillingin, Xanthoxylin, [In 1859, this list had increased to forty-eight items.-L.]

Geo. M. Dixon, Cincinnati, 1856. “We beg leave to call the special attention of the medical profession to our extensive and complete assortment of CONCENTRATED MEDICINES, which are warranted to be as represented, pure and fresh.”

H. H. Hill & Co., (successors to F. D. Hill & Co.), Cincinnati, 1862. “This house was one of the first to introduce the NEW CONCENTRATED REMEDIES. We offer a full assortment of our own articles.”

28. (Afterward, H. M. Merrell & Co. Now Lloyd Brothers.)

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T. L. A. Greve, Cincinnati, 1862. “I keep on hand a full supply of ‘CONCENTRATED MEDICINES’ ”(No list at that date.)

These firms listed their products under titles, such as Alkaloids, Resinoids, Resins, and Concentrated Medicines, some even attempting to group or classify the various substances. But, as a rule, no attempt was made to distinguish between useful agents and those questionable, or between the unworthy and those entitled to a systematic position, by legitimate scientific nomenclature. Through journals and circular prints the physicians of America were now flooded with literature more or less extravagant concerning the marvelous alkaloidal and resinoidal remedies, the outcome being that the few worthy members of the group were soon overshadowed by others either unworthy of the name or entitled to no legitimate home anywhere. A heterogeneous collection was that which was finally included in the commercial lists of resins, resinoids, alkaloids, and concentrations, a list that stands yet in current catalogues. But, as has been said., the odium of it all rested, unfortunately, on the Eclectic school of medicine, by reason of the origin of the first of these
products, the Resin of Podophyllum, and a few other worthy members introduced by Dr. King, as well as from the fact that many overenthusiastic Eclectic physicians had been entrapped in the craze.

After the method of American business rivals of that date, the foregoing manufacturers became bitterly antagonistic, and too often were viciously personal. Uncertain products, illogical processes, extravagant claims concerning the “Concentrations and Alkaloids” prevailed to such an extent as to place all who made them on the defensive. The legitimate use, as well as the misuse of the resinoids, crept gradually into print. Outsiders became involved, antagonistically and otherwise, friends were arrayed against each other, and at last the turmoil centered upon and came near disrupting the Eclectic School of Medicine. In it all, as has been said, very different substances masqueraded under the same name in the various published lists. The differences, and the reasons for the differences, may best be explained by a consideration of their position in pharmacy, and the problems that confronted the overly enthusiastic manufacturers.

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DISCREDITING THE ECLECTIC ALKALOIDAL, REISINOIDAL CONCENTRATIONS.

In the article titled “Podophyllin and Macrotin,” Eclectic Medical Journal, Cincinnati, January, 1849, Mr. Wm. S. Merrell reviewed the articles of Hodgson (1832) and Lewis (1847), who had assayed the root of mayapple. Mr. Merrell also gave his own method of making the resin of podophyllum, which he had named Podophyllin, a name considered proper by himself and others high in authority.

In that article, which, excepting the contributions of Dr. King, was the first paper that seriously considered the pharmacy of these substances, Mr. Merrell announced that the authority for the said name, for giving which, as already stated, (pp. 11-13), he had been severely criticised, was the author of the United States Dispensatory (p. 27)

Following this, (February, 1849, pp. 66 to 68), Dr. John King, in the same journal, gave his part in the record, citing his method, as used in 1835:

In the fall of the year 1835, I produced for the first time some resin of Podophyllum, Macrotys, Iris, and Aletris, also the dried Hydro-alcoholic extracts of Leptandra and Hydrastis. In obtaining the resin of Podophyllum, I made a saturated tincture of the root, which was placed into an equal quantity of water, and the alcohol distilled off; the resin remained at the bottom of the vessel, and had the appearance of a burnt substance, which led me to imagine that it had probably become injured by the mode adopted for its collection.

As the action of the concentrated principles of our remedies is now undergoing investigation, I would refer to my communication named in the commencement of this, for a list of articles worthy of immediate notice, and will mention
several which I have made and used as particularly deserving the ,confidence of physicians: dried hydro-alcoholic extracts of Baptisia Tinctoria, Euphorbia, Ipecac, Hydrastis Can., Phytolacca Dec., Cornus Sericea, Rumex crispus, and Apocynum Cannabinum.—Eclectic Medical Journal, 1849, pp. 66 and 68.

In August, 1849, Dr. S. H. Chase contributed an article commending Leptandrin, to which the editor appended a note, as follows:

We think the value of Leptandrin in dysentery has been thoroughly proved by the experience of the profession in Cincinnati. As a cholagogue remedy of very little purgative power, well calculated to change the morbid diathesis, it is
entitled to a high rank.—Eclectic Medical Journal, 1849, P. 394.

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In October, 1851, the New England Medical and Surgical Journal, in an editorial by Calvin Newton, M. D., answered the “question frequently asked,” and wrote as follows concerning “the comparative efficacy and value of the concentrated preparations of medicines:”

Which have of late been introduced to the notice of the profession. In answer to such inquiries, we will here say, that we have given several of these preparations a pretty fair trial, and some of them we now hold in high estimation, particularly the leptandrin, podophyllin, and the macrotin.

Came now a voluminous flow of questionings concerning the new remedies, their pharmacy, for which extravagant claims were too often made, and their uses, which involved all concerned in the work, be they conservative or otherwise.

In 1850, E. M. Journal, July, pp. 297-305., Mr. Wm. S. Merrell contributed another voluminous article, titled, “Eclectic Pharmacy.”
In it he concedes to Dr. King priority in discovering the resins under discussion.

Justice requires me to state that Dr. John King, now Professor in the Eclectic Medical Institute at Memphis, had previously obtained several of these medicinal principles in a form somewhat less refined, and had successfully
employed them in his practice, and had published some notices of them in the Medical Reformer. But these facts had attracted but little notice, and were wholly unknown to me till after several of my articles had acquired a considerable notoriety.

Whilst thus granting credit of discovery and of therapeutical use, Mr. Merrell, very truly and very properly, claims the credit of introducing the products in commerce. His paragraph on the subject may be repeated:

It is often asked with respect to Podophyllin, Leptandrin, and other analogous preparations, am I the discoverer of these? I answer, I am so, in the same sense that Fulton invented the steamboat -and Morse the electric telegraph. The
power of steam and its application to machinery was known before the time of Fulton, and it had even been applied to the propelling of a boat; but he carried these inventions one step further and first made them of practical utility in
navigation.

The substances mentioned were all prepared after the process of making resin of podophyllum, the process being given as follows:






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